Things are beginning to change in how grass is viewed by us, notably as a drug useful for medical purposes. The mainstream has not embraced this perspective and merely a couple of folks understand precisely how useful this medication is.
Some essential ones would be the following:
Cannabis enhances our sleep and raises our desire.
THC can be utilized to enhance desire among patients, so then CBD may be only the best thing for you personally, if you have ever had any trouble by means of your hunger. This contains arousing weight gain in individuals with anorexia. Different types of studies have revealed THC might help spark the desire even in the event of ailments that were competitive, like cancer and HIV. Furthermore, CBD in conjunction with THC might help people sleep. This is often extremely important in instances of patients afflicted by serious health conditions who have to rest and cure themselves
Cannabis restrains epileptic seizures
(You may read more about it here)
Seizures are muscle spasms that are involuntary and are just one of the very acute outward indications of epilepsy. The issue with standard epilepsy treatments are the unwanted side effects. Headaches, nausea, sleep disturbance, and generally liver failure are only a couple from a very long record of unwanted effects. It’s been repeatedly shown that CBD oil can heal many types of states, from coping with tumour/cancer cells, fixing psychosis, and reducing nausea and vomiting. Research affirms that individuals experiencing epileptic seizures can be helped by CBD oil. As the Epilepsy Foundation implies, “When traditional treatments don’t work, as is the situation for nearly 30% of individuals with epilepsy, it’s not foolish to think about cannabis.”
Cannabis heals continual pain
Cannabis is a well known analgesic for tens of thousands of years. Humankind is appreciating the advantages of an all-natural pain killer minus the disadvantages of utilizing powerful painkiller pills which contain opiates.
That is an outbreak of painkiller dependence in America. Tens and thousands of individuals are addicted to dangerous drug readily prescribed by their physicians. The unwanted side effects tend to be more fatal compared to the relief they’re purportedly offering. This is the reason more folks every day choose to follow the natural manner of pain management. Cannabis has got the skill to alleviate the pain in our muscles and joints, and additionally alleviates harm-associated pain.
Cannabis prevents the growth of Alzheimer’s and reduces its symptoms
Consequently, long-term brain inflammation is reduced by both cannabinoids. Researchers found that treating Alzheimer’s disease patients with medical cannabis oil alongside their present pharmacotherapy is an effective and safe treatment.
Naturally, Cannabis includes a much more medical advantages to offer for a number of other varieties of ailments, and there’s continuing research that demonstrates promising results for future uses.
Warning: The reader of the informative article ought to exercise all precautionary measures while following directions on the home remedies from using this informative article. Avoid if you’re sensitive to it, using any one of these products.
Level and deep-set noses don’t appear pleasant. Reshape and sharpen your nose without injecting filler or having operation. Bid farewell to your broad and level nose eternally! It’s simple get a smaller nose and to reshape your nose. A high bridge nose can make a characters facial features seem more exquisite. A genuinely wonderful girl should possess a high bridge nose. Easterners typically have noses that are flat and submerged plus it’s not exaggerating to say that 90 of our nation folks would not have nose bridges. Using massaging techniques that are particular one can somewhat change the form of the nose cartilage, therefore making the nose bridge seem much more notable and higher. Letâs find the encounter she shared. Two years back, my nose was level and deep-set, my face was round with no chin and my mouth seemed âoverbiteâ. All these didn’t please me and folks called me âDoraemonâ. My mum once challenged me whether I’d gone for rhinoplasty. Once I denied, she remarked that I’d grown up to turn into a pretty girl and rubbed her fingers always. Now letâs find how I did this. Photograph comparison after and before. 1. No have to press too difficult but fairly will do â massage for 1 minute. 2. Of pulling, the focus is the cartilage piece. Implement a bit more than average power with slow motion but with focus. 3. Continue to utilize the massaging fashions clarified in 2, however simply change the place marginally down. The focus is on the nose bridge. Utilizing the ability of the thumbs to try to pull it and also to clasp the nose bridge out. Do this this time. (Normally after finishing this measure the nose bridge turns reddish.) 4. Without altering the location, speedily massage down and up along the nose contour in straight line movement. Massage for 30 seconds and it’s also ended. Items to remember:The most crucial point to keep in mind for any kind of massaging would be to follow the time that is recommended. The next morning it recuperated.) Eventually the massage time was shifted by me for 3 days to rest and FOUR days. I found this more successful because the version of human body require a time interval. Currently the surrounding muscle tissues and also the nose cartilage have grown to be much more sensitive and may react more easily to massaging. They can be stimulated by occasional massage. Lets understand the best way to make your nose smaller and see this video. Sharpen and reshape your nose applying this process that is simple! Make your nose thinner! No demand to really go for fillers or nose job if not rhinoplasty! there are operation neglects like michael jackson nose instance. You are free to work with this tune and monetize your video, but you have to contain the following in your description that is video:That Child in Fourth Grade Who Really Enjoyed the Denver Broncos by Chris Zabriskie is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/)…
Get a colonoscopy
Pavel-L-Photo-and-Video/ShutterstockFor most people, your 50th birthday is the signal that it’s time for a first colonoscopy screening—and you should know the best time to schedule your colonoscopy. During the procedure, your doctor will use a long, lighted tube called a colonoscope to examine your colon for polyps, which can be early signs of colon cancer. The procedure, which is done while you’re under sedation, is painless and the benefits are great. Discovered early, colon cancer is one of the most preventable and treatable forms of cancer—but it rarely has symptoms until it’s progressed to a deadlier stage. According to the Colon Cancer Alliance, colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death in men and women in the United States. Nearly 90 percent of new cases occur in people over age 50. Colon cancer usually begins as a small, slow growing growth in the colon that, if left unchecked, can progress into cancer. “It is a disease that is 90 percent treatable if caught early,” says Michael Sapienza, CEO of the Colon Cancer Alliance. For those fearful of the procedure, which requires sedation and taking a day off of work, other procedures are available, but the colonoscopy is the most complete screening method available because it can identify and remove polyps in a single session and there’s really nothing to be nervous about. Check out these colonoscopy prep tips from doctors. “If you are not doing it for yourself, do it for others—your family,” says Sapienza. While most adults have a first colonoscopy at age 50, those with risk factors such as a family history of colon cancer, may need to be screened at an earlier age.
Visit the eye doctor
Olena-Yakobchuk/Shutterstock“Needing reading glasses is the most annoying sign that says ‘yes you really are aging,'” says Ruth D. Williams, Clinical spokesperson for the American Academy of Ophthalmology. “It’s the first irreversible sign of aging, while others—like weight gain—you can go to the gym to get rid of.” Age-related eye care starts with a baseline eye exam, usually done at age 40, and serves as an important first step because many signs of eye disease are subtle. “Glaucoma is one disease that can develop before the patient realizes it,” says Williams. Other diseases that crop up with age include early cataracts, decreased vision, trouble seeing when driving at night, eye pain, redness, and flashes and floaters in the eye. These are all signs that should prompt a visit to the eye doctor. “A sudden appearance of flashes and floaters can indicate retinal detachment, while trouble with driving at night can be an early indication of cataracts,” says Williams. When it comes to caring for your eyes, the advice is similar to caring for the rest of our health—stop smoking, avoid second-hand smoke, and wear sunglasses that offer 100 percent protection from UV rays. “The bigger the sunglasses, the better,” says Williams. “Protection from the sun helps prevent macular degeneration and cataracts, and wearing big sunglasses also protects the fine skin around the eyes, reducing your chance of getting wrinkles.” Eating colorful fruits and vegetables is also a must for eye health. “Research has shown that eating leafy greens slows the development of glaucoma and decreases the risk of macular degeneration,” says Williams. “I believe the data so much that I put leafy greens in everything I eat.” Check out these foods that can help protect your eyesight.
Start—or keep on—exercising
chaiwarin/ShutterstockRegular exercise has many proven benefits and can help prevent, delay, or manage many of the most common chronic diseases (heart disease, diabetes, osteoporosis, and obesity) that affect adults 50 and older. Despite the many benefits of physical activity, 31 million Americans (28 percent) 50 and older are inactive, according to a study from the Centers for Disease Control and Prevention (CDC). To get on track with exercise, Barbara Bushman, PhD, and author of American College of Medicine’s Complete Guide to Fitness & Health, suggests you find a physical activity that you enjoy and make a commitment to doing it on a regular basis. “Our 50s are stressful—the kids are growing up and we often have to care for aging parents,” says Bushman. “You need to make time and create the mindset for exercise.” Whatever activity you choose, if you want to reap the health benefits of exercise according to the US Department of Health and Human Services, you’ll need to do the equivalent of at least 150 minutes of moderate intensity aerobic physical activity (two hours and 30 minutes) each week. Read more about kick starting your fitness routine.
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Add strength training
Satyrenko/ShutterstockMuscle mass and strength decreases as we age, a phenomenon called sarcopenia. To combat it, you need to lift some heavy stuff, regularly. According to a Tufts University study, research shows that strength-training exercises have the ability to fight weakness and frailty and their debilitating consequences. “You may like to walk, and that’s great, but if you want to be active in your retirement years, you need strength training,” says Bushman. Doing strength-training exercises two to three days a week builds muscle strength and muscle mass. Lifting weights also puts stress on your bones, helping to preserve bone density, which will have thinned by 10 percent by the time you turn 50. Strength training can reduce the risk of osteoporosis and the signs and symptoms of chronic diseases such as heart disease, arthritis, and type 2 diabetes. Lifting weights also can help improve sleep and reduce depression. Bushman says that adding strength training in your fifties will help you stay strong and independent as you age. “When you are ready to retire, will you have the strength to go windsurfing or unload your kayak from your car?” Read more about the importance of strength training.
Make exercise part of your retirement plan
ManuelfromMadridMany of us sit down with a financial planner to ensure we’ll have enough money when we retire, but when it comes to our health we often neglect planning ahead. “Once you get to middle-age you are more prone to see the consequences of inactivity,” says Wojtek J. Chodzko-Zajko, PhD, and dean of the Graduate College at the University of Illinois at Urbana-Champaign and spokesperson for the American College of Sports Medicine. “Decades of being sedentary and poor nutrition will manifest as cardiovascular disease, hypertension, and diabetes, but it’s never too late,” he says. The first step is to add physical activity, but it has to be done in a way that creates balance in your life. “Being physically active decreases the rate of physiological decline as we grow older, but you can’t prescribe physical activity like a drug, you have to find ways to build physical activity into your life, make healthier nutritional choices, and manage the areas in your life that cause stress.” While Chodzko-Zajko says that there are many cognitive programs that promise to help with memory and improve brain function as we age, the best approach is to stay socially engaged, identify hobbies that give you pleasure, and to find physical activity that works for you. It might be walking the dog, going for an after dinner stroll, or going out dancing twice a week. “You have to think ahead and ask yourself ‘what is it that I want to do now, what do I want to do 10 years from now, and how do I get there?'”
Nap away stress
Image-Point-Fr/ShutterstockExercise can protect the hippocampus, the part of the brain that’s responsible for the processing of long-term memory and emotional responses. Stress attacks and damages the anatomy of the cells of the hippocampus, explains Wendy Suzuki, professor of Neural Science and Psychology in the Center for Neural Science at New York University and author of Happy Brain, Happy Life. “Exercise is one part of the prescription for aging, but it is not everything,” she says. She recommends meditation to combat stress and increase attention along with getting enough sleep and taking naps. “Motor memory improves and declarative memory improves with napping, but you have to practice napping to get the most effects.” Check out these 10 benefits of napping.
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Take care of your skin
megaflopp/ShutterstockWrinkles, age spots, dry skin, and loss of elasticity are all changes that you can expect to happen to your skin as you enter your 50s, especially if you have not been good about applying sunblock over the years. “When you enter your fifties, you have to worry about loss of collagen and dryness,” says Rebecca Baxt, MD, board certified dermatologist at Baxt CosMedical in Paramus, New Jersey. So what can you do now to combat these changes? The solution starts with a trip to the dermatologist for regular skin cancer screening and the development of a good skincare program. The risk of skin cancers (basal and squamous cell) increases as people get older as they have been exposed to…
By Dr. Mercola
Years ago, a public service announcement in the U.S. concluded with this powerful statement: “A mind is a terrible thing to waste.” While that tagline promoted an education fund for minority college students, it could just as easily be used to underscore the importance of taking care of your brain health. I say that because of the prevalence of degenerative brain diseases, such as age-related dementia and Alzheimer’s disease.
Like me, you may have coworkers, neighbors, friends and family members who are affected by one of these progressive “mind-robbing” diseases. The numbers of those affected continue to grow at alarming rates, with more than 5 million Americans currently living with Alzheimer’s.1
While it’s terrible to watch a loved one slip away and literally “lose their mind,” it’s also important to remember that dementia and Alzheimer’s are not a normal part of aging. Rather than try to counteract the effects of these diseases once they develop, it’s better to adopt a healthy lifestyle now that will help you successfully avoid them.
Over the years, many studies have considered the effectiveness of ginkgo biloba for the treatment of Alzheimer’s and dementia. The latest research demonstrates ginkgo’s protective effects on the brain when exposed to aluminum chloride, a neurotoxin previously linked to Alzheimer’s and other cognitive impairments.
What Is Ginkgo Biloba and How Does It Help?
Given that the ginkgo tree is among the oldest trees in the world, ginkgo seeds have been used in traditional Chinese medicine and other types of treatment for thousands of years.Over the years, ginkgo has been transformed into capsules, cosmetics, extracts, tablets and teas. Today, ginkgo biloba is a top-selling extract and dietary supplement. Beyond what was mentioned above related to its potential cognitive- and memory-boosting properties, some of ginkgo’s benefits are thought to be as follows:2
- Decreases leg pain caused by narrowing of your arteries (intermittent claudication)
- Treats eye problems, such as age-related macular degeneration, diabetic eye issues and glaucoma
- Supports the treatment of multiple sclerosis, sexual dysfunction and tinnitus, among other health conditions
Ginkgo is believed to positively affect your body by increasing blood supply, reducing blood viscosity, boosting neurotransmitters and reducing harmful free radicals.3
According to WebMD,4 an adult dose of 120 to 240 milligrams (mg) of ginkgo biloba per day seems to be effective for addressing memory problems. Some have suggested even better results may be achieved by taking ginkgo in combination with panax ginseng or codonopsis. In the video below, Tom O’Brien, master herbalist, presents 10 health benefits of ginkgo biloba.
Ginkgo Now Shown to Protect Your Brain Against Aluminum Chloride
In recent years, it has become increasingly clear that aluminum toxicity plays a role in neurodegenerative diseases. Because aluminum targets the same areas of your brain and nervous system, people with aluminum toxicity display many of the symptoms shared by those with attention deficit hyperactivity disorder (ADHD), autism, dementia, Parkinson’s and other neurological diseases.
Inhaling aluminum dust or vapors sends aluminum particles directly into your lungs in a highly absorbable form. From there, they pass into your bloodstream and are distributed throughout your body, including your bones and brain.
Exposure to aluminum is an occupational hazard for workers in agriculture, factories, mining and welding. Furthermore, you ingest aluminum vapors every time your nose catches a whiff of cigarette smoke. Studies of the health effects of aluminum vapors are grim, pointing to high levels of neurotoxicity.5
In a 2016 study published in Nutrition,6 ginkgo biloba was shown to protect the brain from toxicity associated with aluminum chloride. Exposure to aluminum chloride has been linked to Alzheimer’s and other cognitive impairments. The study, which lasted three months, was composed of four groups of lab rats as follows:
- Group 1 (control group): daily normal diet and water
- Group 2: daily oral dose of ginkgo biloba — 200 mg/kilogram (kg) body weight
- Group 3: daily oral dose of aluminum chloride — 10 mg/kg body weight
- Group 4: daily dose of both ginkgo biloba and aluminum chloride through a stomach tube — 200 and 10 mg/kg body weight, respectively
The rats given aluminum chloride showed:
✓ A significant increase in thiobarbituric acid reactive substance (TBARS), which signals damage produced by oxidative stress (similar to rust on your car, oxidative stress is a sign of aging in your body)
✓ A decrease in antioxidants catalase, glutathione and superoxide dismutase in brain and testis tissues
✓ A significant decrease in dopamine, noradrenaline and serotonin levels in brain tissue
✓ A significant decrease in serum copper and zinc levels
✓ A significant increase in serum iron
✓ A significant decrease in testosterone
In contrast, rats administered both ginkgo biloba and aluminum chloride had:
- Lower TBARS
- More of the antioxidants catalase, glutathione and superoxide dismutase in brain and testis tissues
Overall, the research demonstrates that ginkgo biloba plays a positive role in protecting the brain neurons of rats from oxidative stress caused by the intake of aluminum chloride. The study authors stated:7
“The histologic examination showed some degenerative changes in both brain and testis tissues [of the rats receiving aluminum chloride], while significant improvement in biochemical and histologic changes were observed in the ‘aluminum chloride plus ginkgo biloba’ group. It could be concluded that the protective effect of ginkgo biloba may be attributed to its antioxidant properties.”
These findings are in line with previous studies involving the extracts of ginkgo biloba, which are known to contain antioxidant compounds that protect your cells from free-radical damage within your circulatory and nervous systems.8
Ginkgo Also Shown to Help Slow Aging Process in Your Mitochondria
A 2012 study published in International Psychogeriatrics9 suggests ginkgo biloba may slow the aging process within mitochondria of your cells, which can affect the progression of Alzheimer’s. The authors of the study said:
“A growing volume of data confirms that ginkgo biloba extract reduces oxidative stress and improves mitochondrial respiration, and thus may be useful in preventing or slowing down the progression of [Alzheimer’s disease].”
Other research has suggested the mitochondrial anti-aging effect of ginkgo biloba is not limited to just neurons, but also extends to blood platelets, endothelial cells, fibroblasts, heart cells and liver cells.10 Later in this article I will present some diet and lifestyle tips to boost your brain health.
By far, one of the best strategies to support your brain and your mitochondria is to convert your body to burning fat instead of glucose as its primary fuel. You can learn more about metabolic mitochondrial therapy by reading my latest book, “Fat for Fuel.”
Risks and Cautions Related to Ginkgo Intake
According to the U.S. National Center for Complementary and Integrative Health,11 intake of ginkgo biloba is thought to be safe for healthy adults when taken by mouth in moderate amounts. Potential side effects of ginkgo may include allergic skin reactions, dizziness, headache and stomach upset.
An increased risk of bleeding is possible with ginkgo if you are older, pregnant or have a known bleeding risk. Ginkgo has been shown to interact with blood thinners (anticoagulants), so do not take it if you are currently on a blood-thinner medication. For similar reasons, you should not take ginkgo before undergoing surgery or dental procedures. Also, do not eat raw or roasted ginkgo seeds, because they can cause serious side effects and may be poisonous.
A 2013 study12 investigating the potential toxicology of ginkgo suggested consumption of it may raise your risk of developing liver cancer and thyroid cancer. However, that research has come under considerable criticism for the large doses of ginkgo extract that were administered to rodents daily during the two-year study.13
You Need B Vitamins If You Take Ginkgo Biloba
A word of caution related to ginkgo biloba: Its seeds contain ginkgotoxin (4′-O-methylpyridoxine), an “antivitamin” that may lead to neurological problems in certain people, particularly those who are deficient in certain B vitamins.14 B vitamins are important not only when you consume ginkgo, but they are also useful in helping to reduce brain shrinkage and prevent degenerative brain diseases. In particular, folic acid and vitamins B6 and B12 have been shown to play a powerful role in preventing Alzheimer’s.
High levels of the amino acid homocysteine have been linked to brain shrinkage and an increased risk of Alzheimer’s. B vitamins are known to suppress homocysteine. In a 2010 study,15 participants received relatively high doses of the three B vitamins mentioned above. Two years later, those who had received the vitamin-B regimen suffered significantly less brain shrinkage compared to those who had received a placebo.
Participants with the highest levels of homocysteine at the onset of the trial experienced brain shrinkage at half the rate of those taking a placebo. The study authors concluded: “The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.”
A 2014 study by some of the same scientists again underscored the importance of folic acid …
By Dr. Mercola
Research has recently discovered that hot chilies may help soothe your gut when you suffer from inflammatory bowel disease (IBD). IBD is not to be confused with inflammatory bowel syndrome (IBS), which is a less serious functional disorder that doesn’t cause ulcers or intestinal damage as does IBD.
IBD is an autoimmune condition that may have serious consequences. Currently there are nearly 3 million Americans who suffer from IBD, with nearly 70,000 new cases diagnosed each year.1 This is nearly triple previous estimates, which may be due to a combination of rising rates and improved diagnostic criteria.
The rising rates of the condition may be related to genetics, environmental factors, diet and changes in your gut microbiome. Research has demonstrated your microbiome is so important that physicians may even use it as a diagnostic tool.2
While improving your microbiome plays a significant role in reducing or eliminating your symptoms, capsaicin and endocannabinoids may also play a role in reducing your symptoms through control of your neuroimmune axis.3 Before understanding how it works, it’s helpful to understand the condition.
What Is Inflammatory Bowel Disease?
IBD is a chronic inflammation of part or all of your intestinal tract that may result in ulcerations, vomiting, bloody diarrhea and weight loss. The condition is often debilitating and may lead to a life-threatening situation. There are two different types of IBD: Crohn’s disease and ulcerative colitis (UC).
UC is generally more common in men, while more women suffer from Crohn’s disease.4 Both forms of IBD are more common in developed countries, while ex-smokers and nonsmokers more commonly have UC, and smokers more commonly develop Crohn’s.
People who experience UC will often suffer from ulcers and inflammation in the lining of the large intestines, while Crohn’s is a disease that affects your entire digestive tract. Doctors believe your symptoms are the result of widespread recurring immune response focused in your intestines.5
Your immune system mistakes substances in your intestines for a foreign material and sends out white blood cells that trigger inflammation.6 Without significant changes to your lifestyle, symptoms continue to get worse and affect your quality of life.
Unfortunately, the symptoms are often associated with stigma, fear and isolation that have resulted in the disease being relatively hidden and people suffering in silence. While there is no real cure for the condition, there are strategies that may reduce or eliminate your symptoms.
Why Hot Chilies May Calm Your Gut
Recent research has found when mice were fed capsaicin, the substance in chili peppers that makes them “hot,” they had less inflammation in their gut — and some were even cured of a mouse model type 1 diabetes.7 Researchers found capsaicin acted on receptors, causing local production of anandamide.
Anandamide acts through your cannabinoid receptor 2 (CB2) that increases the number and function of immune macrophages in your gut. You have endogenous cannabinoids or endocannabinoids produced in your system from glycerophospholipids. Anadamide is an endogenous intestinal cannabinoid.
It controls your appetite and energy balance through the nervous system in your intestinal tract. This study uncovered the immunological role anandamide and endocannabinoids play in the regulation of immune tolerance in the gut,8 and in maintaining immune homeostasis between the nervous and immune systems.
Following the discovery of endogenous cannabinoid production in the mid-2000s, a large number of studies exploring the system and regulatory function were initiated, as scientists were hopeful for a pharmaceutical approach to health.9
Interactions in the endocannabinoid system are much like those that occur in the brain, as your gut has a very large nervous system affected by the endocannabinoids produced after ingesting chili peppers. Researchers question if people who use edible cannabinoids may experience the same relief.10
What Is Cannabidiol or CBD?
The cannabis plant, commonly known as marijuana, has two major active ingredients. The more famous molecule is tetrahydrocannabinol (THC), known for the psychoactive properties that leave people feeling “high” or “stoned.”11 The second chemical compound found in the cannabis plant is cannabidiol (CBD). This doesn’t have the psychoactive effects but still has an effect on your body. CBD may actually counteract the psychoactivity of THC.12
How much THC and CBD in the plant depends upon the strain. In the past decade much research has been undertaken to ascertain the medical efficacy of CBD in the treatment of specific conditions. There has been promising evidence of positive effects as an antidepressant,13 anti-inflammatory,14 antioxidant15 and neuroprotective.16
Often used in oil form, medicinal cannabis oil is extracted from strains of the plant grown specifically high in CBD and low in THC. CBD works by binding to cannabinoid receptor cells, some heavily concentrated in your nervous system. However, there are receptors in almost every organ of your body.17
The combination of your endogenous cannabinoid and receptors make up your endocannabinoid system, involved in many of your organ systems. However, the four primary purposes appear to be neuroprotection, immune balance, stress recovery and homeostasis regulation.18
Although both THC and CBD are cannabinoids, they react with your body in different ways. THC engages your CBD1 receptors, many of which are in your central nervous system, or brain. Combined with the psychoactive properties, this results in feeling “high.”19
CBD Results Push Further Research
Neurologist Dr. Ethan Russo discussed the difference between THC and CBD and the way they interact with your receptors in an interview with Project CBD. He points out that cannabis has been selectively bred over the years for high THC levels to increase the psychoactive effects of the plant.20
However, the medicinal plant bred for high levels of CBD and low levels of THC do not engage your CBD1 receptors in the same way. He explains:
“It doesn’t tend to bind directly, what’s called the orthosteric site where THC binds. Rather, it binds on what’s called an allosteric site, another site on the receptor, and it so it alters the binding of both THC and the endogenous cannabinoids, the endocannabinoids.
So, cannabidiol is what’s called the negative allosteric modulator, which is a fancy way of saying that when THC is present it interferes with its activity — which is a good thing in terms of wanting too much psychoactivity and again limiting side effects like anxiety or rapid heart rate that can be a problem if someone has too much THC.”
This difference has fueled a group of “medical cannabis refugees,” who have moved to Colorado in search of medicinal plants that have demonstrated unique and powerful success in the treatment of conditions like intractable seizures,21 Parkinson’s disease22,23 and obsessive compulsive disorder.24,25
In the past decade the endocannabinoid system has been implicated in a number of biological and physiological functions that show increasing promise in treatment of a wide variety of disorders, including IBD, neuropathic pain and multiple sclerosis.26
However, while great strides have been made in research, the socially unacceptable psychoactive properties of the cannabis plant have presented a significant challenge to families seeking treatment. The use of selective receptor agonists could potentially improve treatment options.
How CBD May Affect Your Gut Health
Research from the University of Vermont found those who ate red-hot chili peppers experienced a 13 percent reduction in risk of death, primarily from heart disease or stroke.27 Data suggested participants benefited from the result of capsaicin cellular and molecular mechanisms, especially in the gut.
The outcome of an excessive inflammatory response in your gut is intestinal damage and disturbances in motility and secretion — the hallmarks of IBD.28 With no known current pharmaceutical cure, success of treatment modalities is measured by severity of symptoms.
Active inflammation in the gut may be mediated by enteric glial cells that release factors, amplifying the immune response.29 This represents an important connection between your nervous system and immune system inside your gut. CBD can control these glial cells in your nervous system without psychoactivity, and therefore reduce the inflammatory response in your intestinal tract. These results indicate that CBD meets criteria for a therapeutic strategy to treat IBD.30
The gut-brain connection offers a strong explanation of how your intestinal health responds to stress and, conversely, why acute or chronic abdominal distress may result in emotional complaints. CBD is becoming more recognized for the important role it plays in treating this neuroimmune axis.31
And finally, the side-effect profile for CBD oil and other medicinal preparations of CBD is very low. In fact, the preparations have fewer side effects than current medications used to treat UC and Crohn’s disease.32,33
Prevention and Treatment Without Drugs
Like most health conditions, prevention is the best medicine. Your gut bacteria have a powerful influence over your immune system and the inflammatory response in your body as I discuss in the video above.34,35 Individuals who suffer from IBD often share an altered microbiome resulting in a …